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Also, more patients taking Crestor (72%) than Lipitor (56%) saw their LDL levels fall below the 70 mg/dL target set for high-risk heart patients Jun 24, · Not better-different: Both are statins, and work through the same mechanism to lower cholesterol. 31 years experience Cardiology. 0 out of 10 from a total of 22 ratings on Drugs. This is quite a claim, because Lipitor and Zocor are pretty strong themselves. Both drugs come in tablet form only that Zocor is available in 5mg to 80mg dosages while Crestor is made in 5mg to 40mg. In clinical studies, Crestor (rosuvastatin) has the strongest effect on lowering "bad" cholesterol compared to other statins. Crestor is the more potent cholesterol-lowering drug, and it's also newer than Zocor. Rarely, both drugs may cause liver, muscle, and kidney damage 2. Zocor is taken before bedtime while Crestor can be taken any time of the day. View all 101 reviews View all 22 reviews. Hence the latter should be tried at lower dose. 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