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Similar, but differ: Both are bisphosphonate drugs, taken orally, which decrease bone breakdown by osteoclast cells, and therefore increase bone density (a marker of bone strength). It is called Reclast ( ledronic acid). Fosamax Head-to-head comparisons of medication uses, side effects, ratings, and more. Different dosing, but can be weekly or monthly for either in osteoporosis Prevents bone loss and fracture. Generics are absolutely as effective as the brand name. Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle There are studies comparing both drugs, Fosamax and Actonel, and some studies come out showing Fosamax to be more preferred compared to Actonel. Glucocorticoid-induced osteoporosis. No i dont think evista is better infact since it is perscribed less often i am thinking it is not as effectivei only mentioned it because i have tried fosamax ,actonel, and was not able to tolerate themthey gave me urinary problems (6 replies). 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Pills, such as alendronate (Fosamax), ibandronate (Boniva), or risedronate (Actonel, Atelvia), taken daily, weekly, or monthly; injections of ibandronate (Boniva), given once every three months; intravenous infusion of zoledronic acid (Reclast), given once a year. Actonel (made by Procter & Gamble) and Fosamax. Any thoughts on what might be best? 7 out of 10 from a total of 325 ratings on Drugs. Actonel has an average rating of 2. Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle. Actonel (risedronate) Prescription only Fosamax (alendronate) Prescription only Prevents bone loss and fracture. 27, 2006 -- Actonel and Fosamax both prevent bone loss after menopause. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take. 15% of reviewers reported a positive effect, while 73% reported a negative effect. 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