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Promethazine is an antihistamine which treats symptoms such as sneezing, itchy or watery eyes, and runny nose, while codeine is a cough suppressant which helps relieve a person of a severe cough. Less common are itching, nausea, vomiting, dry mouth, miosis, orthostatic hypotension, urinary retention, euphoria, and dysphoria. I then got some codeine tablets and did a CWE on twelve of them. Promethazine with Codeine Oral Solution is indicated for the temporary relief of coughs and casodex and zoladex upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. This medication may sound harmless, but codeine is an opioid narcotic that can lead a person to become dependent on and maybe even addicted to the drug Promethazine (commonly sold as Phenergan or Lergigan) is a depressant substance of the phenothiazine class. 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